Product Type: | Injection |
Brand Name: | Arlak Biotech |
Packaging Type | VIAL |
Packaging: | 1.5 gm |
Composition / Material Type: | Cefoperazole & sulbactam injection |
Usages: | Inject |
SIGBECT-S 1.5 GM INJECTION
COMPOSITION: - CEFOPERAZONE 1000 MG & SULBACTUM 500 MG
PACKING: - Vial
M.R.P: - 189
Pharmacology
Cefoperazone
Pharmacodynamics:- Cefoperazone is a 3rd generation cephalosporin which exerts its bactericidal action against both gram positive & gram negative organisms by inhibiting bacterial cell wall synthesis. Cefoperazone inhibits Transpeptidase & thus prevents cross linking of bacterial cell wall. Transpeptidase & associated proteins constitute various types of specific binding proteins which have affinity for cephalosporin’s like Cefoperazone. It has greater action against pseudomonas & has good action against salmonella typhi & B.fragilis.
Pharmacokinetics
Sulbactum
Pharmacodynamics: – Sulbactam has no significant antimicrobial activity, despite sharing the?-lactam ring that is characteristic of beta-lactam antibiotics. This similarity in chemical structure helps the Sulbactam to act as a competitive inhibitor of beta-lactamase enzyme secreted by certain bacteria that are resistant to beta-lactam antibiotics. This inhibition restores the antibacterial activity of beta-lactam antibiotics against Beta-lactamase-secreting resistant bacteria. It is usually given in combination with Amoxycillin. It is used to increase the antibacterial spectrum of penicillin and cephalosporin against penicillinase-producing and beta-lactamase-producing organisms such as Staphylococcus aureus, H. flu, Moraxella catarrhalis that are resistant to Ampicillin alone.
INDICATIONS Cefoperazone Meningitis Biliary infections Septicemia Infections in immune compromised patients Urinary tract &genital tract infections Surgical prophylaxis Skin & soft tissue infections Bone & Joint infections Gonorrhea Sulbactam Skin infections Intra abdominal infections Gynecologic infections.