Barec D

COMPOSITION: - RABEPRAZOLE 20 MG + DOMPERIDONE 30MG

Packing: - 10X10

M.R.P: - 650

RABEPRAZOLE  is widely utilized to prevent and heal gastrointestinal (stomach and guts) problems, which is caused due to overmuch stomach acid. Rabebrazole is a proton pump inhibitor (PPI), sometimes identified as an ulcer healing drug. This is also very beneficial for inhibiting secretion and gastric from the stomach as well as to treat various acid related gastrointestinal conditions. It heals stomach and intestinal ulcers and manages gastro-esophageal reflux disease (GORD a condition in which acid rises up from the stomach into the esophagus with symptoms of heartburn, acid regurgitation and pain on swallowing).

DOMPERIDONE is a dopamine antagonist with anti-emetic properties domperidone does not readily cross the blood-brain barrier. Its anti-emetic effect may be due to a combination of peripheral (gastro kinetic) effects and antagonism of dopamine receptors in the chemoreceptor trigger zone, which lies outside the blood-brain barrier in the area postrema. Studies in man have shown oral domperidone to increase lower esophageal pressure, improve antroduodenal motility and accelerate gastric emptying. There is no effect on gastric secretion.

PHARMACOLOGY

1. RABEPRAZOLE sodium is a proton pump inhibitor. It is a prodrug. After administration it diffuses in to the parietal cell of the stomach and accumulates in the secretory canaliculi. In the acidic medium Rabeprazole is converted to sulfenamide. This sulfenamide covalently interacts with sulfhydryl (SH) group in the proton pump (H+ K+ATPase) and inhibits the exchange of extracellular K+ for intracellular H+ ion. Rabeprazole sodium irreversibly inhibits proton pumps activity and decreases gastric acid secretion. Rabeprazole produces fastest acid suppression and helps in mucin synthesis.
2. DOMPERIDONE is a potent dopamine receptor antagonist. It acts centrally and blocks the Dopamine receptor in the Chemoreceptor trigger zone and produces Antiemetic effect. Domperidone acts peripherally in the gastrointestinal system and increases esophageal peristalsis, esophageal sphincter pressure and gastric motility. These all facilitates gastric emptying. Domperidone is used in migraine to relieve nausea and vomiting. Anesthetic adjuncts: It is used preoperatively in order to reduce the post operative vomiting.
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PHARMACOKINETICS:

1.Rabeprazole

Absorption: Rabeprazole sodium is well absorbed after oral administration and its bioavailability is about 50% since it undergoes first pass metabolism.

Distribution: It is widely distributed in the body in protein bound form.

Metabolism: Rabeprazole sodium is extensively metabolized in the liver.

Excretion: It is excreted mainly in the urine and small amount in feces.

2. Domperidone

Absorption: Domperidone is rapidly absorbed after oral administration. Since it undergoes first pass metabolism oral bioavailability is only 15 %.

Distribution: It is widely distributed in the body in protein bound form.

Metabolism: Domperidone undergoes metabolism in the liver.

Excretion: It is excreted mainly in the feces and also in the urine.

INDICATIONS: Gerd, Heart Burn & Hyperacidity. Reflux Oesophagitis. Regurgitation & Flatulance, Gastric & Peptic Ulcer.