BRAND NAME: -SIGBECT-S 1G

COMPOSITION: - CEFOPERAZONE 500 MG + SULBACTUM 500 MG

Packing: - Vial

M.R.P: - 159

PHARMACOLOGY

1. CEFOPERAZONE

a.) Pharmacodynamics: – SIGBECT-S 1G, Cefoperazone is a 3rd generation cephalosporin which exerts its bactericidal action against both gram positive & gram negative organisms by inhibiting bacterial cell wall synthesis. Cefoperazone inhibits Transpeptidase & thus prevents cross linking of bacterial cell wall. Transpeptidase & associated proteins constitute various types of specific binding proteins which have affinity for cephalosporin’s like Cefoperazone. It has greater action against pseudomonas & has good action against salmonella typhi & B.fragilis

b.) Pharmacokinetics: –

Absorption: Orally not well absorbed & should be given parenteral.

Distribution: widely distributed & good CSF penetration.

Metabolism: It is not significantly metabolized inside the body.

Excretion: Excreted mainly through bile & a small portion is excreted in urine. A small amount is seen in breast milk.

2 SULBACTUM

1. Pharmacodynamics: – Sulbactam has no significant antimicrobial activity, despite sharing the?-lactam ring that is characteristic of beta-lactam antibiotics. This similarity in chemical structure helps the Sulbactam to act as a competitive inhibitor of beta-lactamase enzyme secreted by certain bacteria that are resistant to beta-lactam antibiotics. This inhibition restores the antibacterial activity of beta-lactam antibiotics against?-lactamase-secreting resistant bacteria.
2. It is usually given in combination with Amoxycillin.

a.)It is used to increase the antibacterial spectrum of penicillin and cephalosporin against penicillinase-producing and beta-lactamase-producing organisms such as Staphylococcus aureus, H. flu, Moraxella catarrhalis that are resistant to Ampicillin alone.

INDICATIONS:

1. Cefoperazone: Meningitis Biliary infections Septicemia Infections in immune compromised patients Urinary tract &genital tract infections Surgical prophylaxis Skin & soft tissue infections Bone & Joint infections Gonorrhea, Peritonitis.

2. Sulbactam Skin infections Intra abdominal infections Gynecologic infections