Product Type: | Suspension |
Brand Name: | Arlak Biotech |
Packaging Type | Bottle |
Packaging: | 30 ml |
Composition / Material Type: | Ofloxacin & Oranidazole Suspension |
Usages: | oral use |
POLKA-OZ SYRUP
COMPOSITION: - OFLOXACIN 50 MG& ORNIDAZOLE 50 MG
PACKING: - 30Ml
M.R.P: -38
PHARMACODYNAMICS
OFLOXACIN is a quinolone/fluoroquinolone antibiotic. Ofloxacin is bactericidal and its mode of action depends on blocking of bacterial DNA replication by binding itself to an enzyme called DNA gyrase, which allows the untwisting required to replicate one DNA double helix into two. Notably the drug has 100 times higher affinity for bacterial DNA gyrase than for mammalian. Ofloxacin is a broad-spectrum antibiotic that is active against both Gram-positive and Gram-negative bacteria.
Mechanism of action:-Ofloxacin acts on DNA gyrase and toposiomerase IV, enzymes which, like human topoisomerase, prevents the excessive supercoiling of DNA during replication or transcription. By inhibiting their function, the drug thereby inhibits normal cell division.
ORNIDAZOLE
Mechanism of Action: - Ornidazole is a nitro imidazole which has broad spectrum cidal activity against Protozoa and some anaerobic bacteria. Its selective toxicity to anaerobic microbes involves
1. Drug enters the cell by diffusion,
2. Nitro group of drug is reduced by redox proteins present only in anaerobic organisms to reactive nitro radical which excerts cytotoxic action by damaging DNA and other critical biomolecules.
3. DNA helix destabilization &strand breakage has been observed.
INDICATIONS: -