PODZY-100 SYRUP

COMPOSITION: - CEFPODOXIME 100MG

PACKING: - 30 ML

M.R.P: -115

Pharmacology

Absorption and Excretion: Cefpodoxime Proxetil is a prodrug that is absorbed from the gastrointestinal tract and de-esterified to its active metabolite, cefpodoxime. The oral administration of 100 mg of Cefpodoxime Proxetil to fasting subjects, approximately 50% of the administered cefpodoxime dose was absorbed systemically. Over the recommended dosing range (100 to 400 mg), approximately 29 to 33% of the administered cefpodoxime dose was excreted unchanged in the urine in 12 hours.

There is minimal metabolism of cefpodoxime in vivo.

Pharmacokinetics of Cefpodoxime- Over the recommended dosing range, the rate and extent of cefpodoxime absorption exhibited dose-dependency; dose-normalized Cmax and AUC decreased by up to 32% with increasing dose. Over the recommended dosing range, the Tmax was approximately 2 to 3 hours and the T1/2 ranged from 2.09 to 2.84 hours.

INDICATIONS: - Urinary tract infection sinusitis post-operative infection gynacological infection skin & soft tissue infection community acquired pneumonia chronic bronchitis