Product Type: | Tablets |
Brand Name: | Arlak Biotech |
Packaging Type | Strip |
Packaging: | 10*10 |
Composition / Material Type: | Rabeprazole Sodium Tablets IP |
Usages: | oral use |
Barec 20
RABEPRAZOLE 20 MG + DOMPERIDONE 30MG SR
Packing : 10x10 Alu-Alu
MRP : Rs 720/- per 100 Caps
RABEPRAZOLE is widely utilized to prevent and heal gastrointestinal (stomach and guts) problems, which is caused due to overmuch stomach acid. Rabebrazole is a proton pump inhibitor (PPI), sometimes identified as an ulcer healing drug. This is also very beneficial for inhibiting secretion and gastric from the stomach as well as to treat various acid related gastrointestinal conditions. It heals stomach and intestinal ulcers and manages gastro-esophageal reflux disease (GORD a condition in which acid rises up from the stomach into the esophagus with symptoms of heartburn, acid regurgitation and pain on swallowing).
DOMPERIDONE is a dopamine antagonist with anti-emetic properties domperidone does not readily cross the blood-brain barrier. Its anti-emetic effect may be due to a combination of peripheral (gastro kinetic) effects and antagonism of dopamine receptors in the chemoreceptor trigger zone, which lies outside the blood-brain barrier in the area postrema. Studies in man have shown oral domperidone to increase lower esophageal pressure, improve antroduodenal motility and accelerate gastric emptying. There is no effect on gastric secretion.
PHARMACOLOGY
PHARMACOKINETICS: 1.Rabeprazole
Absorption: Rabeprazole sodium is well absorbed after oral administration and its bioavailability is about 50% since it undergoes first pass metabolism.
Distribution: It is widely distributed in the body in protein bound form.
Metabolism: Rabeprazole sodium is extensively metabolized in the liver.
Excretion: It is excreted mainly in the urine and small amount in feces.
Domperidone
Absorption: Domperidone is rapidly absorbed after oral administration. Since it undergoes first pass metabolism oral bioavailability is only 15 %.
Distribution: It is widely distributed in the body in protein bound form.
Metabolism: Domperidone undergoes metabolism in the liver.
Excretion: It is excreted mainly in the feces and also in the urine.
INDICATIONS: