RION-375

COMPOSITION: - AMOXYCILLIN TRIHYDRATE 250 MG+ CLAVULANIC ACID 125 MG

PACKING: - 10X1X10

M.R.P:- 1500

Amoxicillin is a semi synthetic penicillin with a broad spectrum bactericidal activity, and has good oral absorption. It acts through the inhibition of biosynthesis of cell wall. Potassium Clavulanate: - act as an inhibitor of Beta-lactamases of Gram +ve and Gram -ve pathogenic bacteria. Has a protective effect on Amoxicillin. Clavulanic acid when combined with Amoxicillin extends the antibacterial spectrum of Amoxicillin to include organisms resistant to Amoxicillin and other beta-lactam antibiotics, It has been demonstrated by recent studies that Amoxycillin and potassium clavunate shows significantly better symptoms relief with the modest improvement of Upper and lower respiratory tract infections.

PHARMACOLOGY:-

PHARMACOKINETICS:

ABSORPTION: Dosing in the fasted or fed state has minimal effect on the pharmacokinetics of amoxicillin. While amoxicillin/clavulanate potassium can be given without regard to meals, absorption of clavulanate potassium when taken with food is greater relative to the fasted state. In one study, the relative bioavailability of clavulanate was reduced when amoxicillin/clavulanate potassium was dosed after eating something.

DISTRIBUTION: Component in amoxicillin/clavulanate potassium is highly protein-bound; clavulanic acid is approximately 25% bound to human serum and amoxicillin approximately 18% bound. Amoxicillin diffuses readily into most body tissues and fluids with the exception of the brain and spinal fluid.

METABOLISM AND EXCRETION: The half-life of amoxicillin after the oral administration of amoxicillin/clavulanate potassium is 1.3 hours and that of clavulanic acid is 1 hour. Approximately 50% to 70% of the amoxicillin and approximately 25% to 40% of the clavulanic acid are excreted unchanged in urine during the first 6 hours after administration of a single 250 mg/125 mg or 500 mg/125 mg tablet of amoxicillin/clavulanate potassium.

Indications and Usage:

• Upper and lower respiratory tract infection.
• Otitis Media (inflammation of the middle ear).
• Acute Sinusitis.
• Acute exacerbation of chronic bronchitis.
• Pneumonia.